产品描述:
Cladosporin is a microbial metabolite originally isolated from C. cladosporiodes that has diverse biological activities.{66747,66746,66748} It selectively inhibits P. falciparum lysyl-tRNA ligase over human lysyl-tRNA ligase (IC50s = 0.061 and >20 µM, respectively).{66747} Cladosporin inhibits the replication of eight strains of Plasmodium with IC50 values ranging from 45.4 to 89.6 nM and decreases P. falciparum protein synthesis by 75% at 610 nM. It is active against the bacteria M. flavus (MIC = 40 µg/ml) and inhibits spore germination by the plant pathogenic fungi P. viridicatum when used at a concentration of 5 µg/ml.{66746} Cladosporin (30 µM) inhibits the growth of the plant pathogenic fungi C. acutatum, C. fragariae, C. gloeosporioides, and P. viticola.{66748}