产品描述:
Afoxolaner is an isoxazoline insecticide and acaricide.{54762} It is a GABA receptor antagonist that inhibits GABA-induced currents in P. americana thoracic neurons (IC50 = 10.8 nM). It induces mortality in 100% of C. felis after 24 and 48 hours when used at concentrations of 0.32 and 0.16 µg/ml in an artificial membrane blood feeding device. Afoxolaner (2.5 mg/kg) eradicates C. felis infestation in dogs for up to 42 days and D. variabilis infestation for up to 30 days.