产品描述:
Hydroxyurea is an antineoplastic agent that inhibits DNA replication and cell proliferation and induces cell cycle arrest in the G1/S phase.{38524} It inhibits proliferation of NCI H460 human lung cancer cells in vitro (IC50 = 0.56 mM).{38533} Hydroxyurea reduces ribonucleoside diphosphate reductase (RNR) activity by 75% when used at a concentration of 5 mM via degradation of its active site tyrosyl radical.{38524,38534} In a humanized mouse model of sickle cell disease (SCD), it reduces leukocyte adhesion and extravasation via NO production and a cGMP-dependent pathway.{38535} Hydroxyurea also inhibits HIV-1 viral replication in peripheral blood mononuclear cells (PBMCs) in a dose-dependent manner with an IC90 value of 0.4 mM.{38536,38528} Formulations containing hydroxyurea have been used to treat cancer, SCD, and psoriasis.{38524,38525,38527}