产品描述:
UNC6934 is an inhibitor of the protein-protein interaction between histone-lysine N-methyltransferase NSD2 and dimethylated lysine 36 histone 3 (H3K36me2) nucleosomes (IC50 = 104 nM).{72186} It binds to NSD2 (Kd = 92 nM). UNC6934 also inhibits the serotonin transporter (SERT) and μ-opioid receptor (Kis = 1.4 and 8 µM, respectively). It induces NSD2 nucleolus accumulation in U2OS cells when used at a concentration of 5 µM.