产品描述:
6-ECDCA-d4 is intended for use as an internal standard for the quantification of 6-ECDCA (Item No. 11031) by GC- or LC-MS. 6-ECDCA is a synthetic bile acid that acts as a potent and selective agonist of the farnesoid X receptor (FXR; EC50 = 99 nM).{20705} Through FXR, it alters gene expression that results in protection against cholestasis, as well as liver fibrosis, in animal models.{20705,20702,20703} 6-ECDCA also, through FXR, promotes the differentiation of adipocytes and enhances insulin signaling in mature adipocytes.{20707} In ApoE-/- mice, 6-ECDCA ameliorates vascular calcification secondary to chronic kidney disease without affecting the development of atherosclerosis.{20704}