产品描述:
Aranidipine is an antagonist of voltage-gated calcium channel Cav3.2.{39643} It inhibits inward currents in Xenopus oocytes expressing human Cav3.2 channels when used at a concentration of 10 µM. Aranidipine (10 mg/kg) decreases mean blood pressure and increases heart rate in spontaneously hypertensive rats (SHRs).{69819} It increases aortic and coronary blood flow and decreases blood pressure, but not heart rate, in normotensive dogs when administered at a dose of 0.3 mg/kg. Aranidipine (10 µg/kg) decreases blood pressure, as well as increases coronary blood flow velocity and heart contractile force, in dogs.{69820} It inhibits diet-induced increases in serum levels of total cholesterol, phospholipids, and triglycerides, as well as reduces aortic plaque area, in rabbits fed a high-cholesterol diet when administered at doses of 3 or 10 mg/kg. Formulations containing aranidipine have been used in the treatment of hypertension.