产品描述:
Tri-GalNAc COOH is an intermediate in the synthesis of lysosome-targeting chimeras (LYTACs) containing a triad of the galactose amino sugar derivative GalNAc (Item No. 31728) connected by acyl-amino chains to an ether linker with a terminal carboxylic acid that can be functionalized with antibodies or biotin.{72391} It has been used in the synthesis of LYTACs functionalized with anti-EGFR antibodies that reduce EGFR levels without affecting total protein levels in HepG2 hepatocellular carcinoma cells.