产品描述:
THAL-SNS-032 is a proteolysis-targeting chimera (PROTAC) containing the cyclin-dependent kinase 2 (Cdk2), Cdk7, and Cdk9 inhibitor SNS-032 (Item No. 17904) linked to a cereblon (CRBN) binding moiety.{58685} It selectively induces degradation of Cdk9 over Cdk1, Cdk2, and Cdk7 in MOLT-4 cells when used at a concentration of 250 nM. THAL-SNS-032 inhibits human cytomegalovirus (HCMV) replication in infected human foreskin fibroblasts (HFFs; EC50s = 0.025 µM).{68801} It also inhibits viral replication in murine CMV-infected mouse embryonic fibroblasts (MEFs; EC50 = 0.22 µM).