产品描述:
TL12-186 is a proteolysis-targeting chimera (PROTAC) containing a multi-kinase inhibitor linked to a cereblon (CRBN) binding moiety.{66812} It binds to CRBN (IC50 = 12 nM) and inhibits 193 kinases by greater than 90% in cell-free assays. TL12-186 (1-10,000 nM) inhibits the proliferation of wild-type CRBN-expressing but not CRBN-/- MOLM-14 and MOLT-4 cells.