产品描述:
LD003 is a lipid prodrug form of the synthetic glucocorticoid dexamethasone (Item No. 11015) that has been used in the formation of lipid nanoparticles (LNPs) for siRNA and mRNA delivery in vivo.{68925} LNPs containing LD003 and encapsulating cytosine-guanine-containing oligodeoxynucleotide (CpG) reduce the blood levels of Il-10, chemokine (C-X-C motif) ligand 1 (CXCL1), TNF-α, IL-1β, and IL-6 in mice. LNPs containing LD003 and encapsulating siRNA targeting mouse coagulation Factor VII (FVII) decrease injection site immune infiltration and hepatic levels of FVII in mice.