产品描述:
KMH-233 is an inhibitor of L-type amino acid transporter 1 (LAT1; IC50 = 18.2 µM).{59294} It is selective for LAT1 over LAT2 (IC50 = >1,000 µM). KMH-233 (25 and 100 µM) reduces the viability of MCF-7 cells and enhances cell death induced by bestatin (Item Nos. 21217 | 70520) or cisplatin (Item No. 13119) in the same cells. It also reduces mTOR and NF-κB levels and induces apoptosis in MCF-7 cells when used at a concentration of 100 µM.{51762}