产品描述:
Surfen is an antagonist of cell surface glycosaminoglycans.{51810,51811} It binds to heparin, dermatan sulfate, heparan sulfate, and chondroitin sulfate and prevents heparin-induced inhibition of Factor Xa in cell-free assays.{51810} Surfen inhibits FGF2 binding to CHO cells (IC50 = 5 µM) and FGF2-induced tube formation by primary mouse endothelial cells. It also inhibits neural differentiation and increases pluripotency in murine embryonic stem cells (mESCs) when used at a concentration of 5 µM.{51811}