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产品名称:
Urolithin A
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别名:
3,8-Dihydroxy-6H-dibenzo[b,d]pyran-6-one; or 2',7-Dihydroxy-3,4-benzocoumarin
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产品描述:
Mitophagy inducer
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反应种属:
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宿主来源:
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实验应用:
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靶标/特异性:
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同种型:
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推荐稀释度:
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免疫原:
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克隆性:
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纯化方式:
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偶联:
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产品浓度:
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表达系统:
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阳性对照:
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保存温度:
-20ºC
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运输温度:
Shipped Ambient
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细胞定位:
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预期分子量:
228.2
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产品形式:
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存储溶液:
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有效期:
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产地:
加拿大
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外观:
Pale-yellow powder
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生产商:
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功能与背景:
Urolithin A (UA) is a microbial metabolite of dietary ellagitannins produced in the gut (1). It has been shown to induce mitophagy and prolong lifespan in C. elegans and increase muscle function in rodents (2). It promotes mitophagy and suppresses NLRP3 inflammasome activation in LPS-induced BV2 microglial cells and in an MPTP-induced Parkinson’s disease model (3). The pro-mitophagy activity of Urolitin A may be beneficial in Alzheimer’s disease (4). Ex vivo UA-treated T cells display improved anti-tumor function (5).
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URL:
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产品特点:
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纯度:
>98% (HPLC); NMR (Conforms)
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生物活性:
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内毒素水平:
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来源:
Synthetic
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表达方式:
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Accession #:
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CAS号:
1143-70-0
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分子式:
C13H8O4
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溶解度:
May be dissolved in DMSO (50 mg/ml)
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PubChem CID: