产品描述:
CH 275 is a cyclic peptide agonist of somatostatin receptor 1 (SST1; IC50 = 30.9 nM for the human receptor).{51825} It is selective for SST1 over SST2, SST3, SST4, and SST5 (IC50s = >10,000, 345, >1,000, and >10,000 nM, respectively, for the human receptors). CH 275 (500 nM) inhibits basal growth hormone secretion from primary mouse pituitary cells.{51826} It inhibits glucose-induced increases in electrical activity without inducing membrane hyperpolarization in a whole-cell patch-clamp assay using MIN6 pancreatic β-cells when used at a concentration of 100 nM.{51827}