产品描述:
Utreglutide is a G protein-biased peptide agonist of glucagon-like peptide 1 receptor (GLP-1R).{69852} It selectively induces cAMP accumulation in HEK293 cells expressing human GLP-1R over β-arrestin recruitment in CHO-K1 cells expressing human GLP-1R (EC50s = 0.63 and 79 nM, respectively). Utreglutide induces insulin secretion in INS-1 832/3 rat insulinoma cells (EC50 = 6.3 nM). In vivo, utreglutide (1.5-6 nmol/kg) reduces food intake and body weight, increases plasma insulin levels, and decreases plasma glucose, hemoglobin A1c (HbA1c), glucagon, and triglyceride levels in diabetic db/db mice.