产品描述:
CCT369260 is a degrader of Bcl-6.{66847} It induces degradation of Bcl-6 in SU-DHL-4, OCI-LY1, and Karpas-422 cells with half-maximal degradation concentration (DC50) values of 0.09, 0.049, and 0.062 µM, respectively. CCT369260 inhibits the growth of SU-DHL-4, OCI-LY1, and OCI-Ly3 cancer cells (GI50s = 0.092, 0.035, and 1.6 µM, respectively). It reduces intratumoral Bcl-6 levels in an OCI-LY1 lymphoma mouse xenograft model for up to ten hours after administration of a 15 mg/kg dose.