产品描述:
4A3-SC8 is an ionizable cationic lipid (pKa = 6.66) and a dendrimer that has been used in the preparation of lipid nanoparticles (LNPs).{66425,66428} Intratumoral administration of LNPs containing 4A3-SC8 and encapsulating homologous double-strand repair (HDR) elements correct the DNA encoding GFP with a tyrosine-to-histidine mutation at position 66 (GFPY66H) in a HEK293 mouse xenograft model.{66428}