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产品名称:
Borrelidin
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别名:
Treponemycin; U 78548; C2989
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产品描述:
Macrolide antibiotic. Bacterial, protozoan and mammalian threonyl-tRNA synthetase (THrRS) inhibitor. Antiangiogenic (IC50 = 0.8 nM) and anticancer agent. Induces the collapse of formed capillary tubes in a dose-dependent fashion. In HUVECs, the capillary tube collapsing activity is mediated by the activation of caspases-3 and -8 and induction of apoptosis. Blocks the formation of spontaneous lung metastases of B16-BL6 melanoma cells. Cyclin-dependent kinase (CDK) inhibitor. Antiviral. Potent antimalarial agent (IC50 = 0.97 nM). Inhibitor of potato scab disease.
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反应种属:
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宿主来源:
Isolated from Streptomyces sp.
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实验应用:
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同种型:
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表达系统:
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阳性对照:
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保存温度:
-20°C
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运输温度:
Ambient
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细胞定位:
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预期分子量:
489.6
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产品形式:
solid
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存储溶液:
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有效期:
Stable for at least 1 year after receipt when stored at -20°C. After reconstitution protect from light at -20°C.
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产地:
瑞士
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纯度:
>98% (HPLC)
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Accession #:
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CAS号:
7184-60-3
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分子式:
C28H43NO6
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溶解度:
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PubChem CID: