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Concanamycin A (high purity)
品牌： Adipogen
产品货号： BVT-0237-C025
规格： 25 ug

报价：
折后价：

数量： - +
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  • 产品名称:
    Concanamycin A (high purity)
  • 别名:
    Folimycin; Antibiotic TAN 1323B; Antibiotic X4357B
  • 产品描述:
    Antibiotic. More potent and specific H+-ATPase inhibitor than bafilomycin A1 (Prod. No. BVT-0252). Inhibits acidification of organelles such as lysosomes and the Golgi apparatus. Inhibitor of autophagic degradation by rising lysosomal pH and thus inactivating the lysosomal acid hydrolases. Blocks cell surface expression of viral glycoproteins without affecting their synthesis. Cytotoxic in a number of cell lines in a cell viability assay. Induces nitric oxide (NO) production. Concanamycin A enables the immune system to kill HIV-infected cells. Nef is an HIV-encoded accessory protein that enhances pathogenicity by down-regulating major histocompatibility class I (MHC-I) expression to evade killing by cytotoxic T lymphocytes (CTLs). Concanamycin A has been identified as potent inhibitor of Nef that restores MHC-I and enhances the clearance of HIV-infected primary cells by cytotoxic T lymphocytes. Concanamycin A counteracts Nef from diverse clades of HIV targeting multiple allotypes of MHC-I, indicating the potential for broad therapeutic utility.
  • 反应种属:
  • 宿主来源:
    Isolated from Streptomyces sp.
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  • 阳性对照:
  • 保存温度:
    -20°C
  • 运输温度:
    Ambient
  • 细胞定位:
  • 预期分子量:
    866.1
  • 产品形式:
    solid
  • 存储溶液:
  • 有效期:
    Stable for at least 1 year after receipt when stored at -20°C. After reconstitution protect from light at -20°C.
  • 产地:
    瑞士
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  • 纯度:
    >98% (HPLC)
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  • CAS号:
    80890-47-7
  • 分子式:
    C46H75NO14
  • 溶解度:
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