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产品名称:
Leucettine L41
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别名:
(5Z)-5-(1,3-Benzodioxol-5-yl)methylene-2-phenylamino-3,5-dihydro-4H-imidazol-4one
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产品描述:
Potent inhibitor of DYRKs (DYRK1A (IC50=40nM); DYRK2 (IC50=35nM)) and CLKs (CLK1, CLK3). Interacts also with GSK-3alpha/beta, CK2 and PIM1. Interacts with the complex PIKfyve/Vac14/Fig4. Modulates alternative splicing of pre-mRNA in various cellular systems. Neuroprotective against APP-induced cell death. Tools to study and modulate pre-RNA splicing. Potential compound for Alzheimer's disease and diseases involving abnormal pre-mRNA splicing. Potential compound to study Down syndrome (inhibition of DYRK1A). Neuroprotective against glutamate-induced cell death. Autophagy activator.
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阳性对照:
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保存温度:
-20°C
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运输温度:
Ambient
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细胞定位:
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预期分子量:
307.3
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产品形式:
solid
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存储溶液:
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有效期:
Stable for at least 2 years after receipt when stored at -20°C.
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产地:
瑞士
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纯度:
>98% (NMR)
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CAS号:
1112978-84-3
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分子式:
C17H13N3O3
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溶解度:
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PubChem CID: