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产品名称:
GSK-F1
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别名:
5-(2-Amino-4-oxo-3-(2-(trifluoromethyl)phenyl)-3,4-dihydroquinazolin-6-yl)-N-(2,4-difluorophenyl)-2-methoxypyridine-3-sulfonamide; GSKF1
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产品描述:
GSK-F1 is a potent PI4KA inhibitor. It has better pharmacokinetic properties in vivo than to GSK-A1 (SYN-1219). GSK-F1 does not cross the blood-brain barrier. Phosphatidylinositol 4-kinase type IIIalpha (PI4KA) is a host factor essential for hepatitis C virus replication and hence is a target for drug development. RNAi studies have shown that PI4KA is a mandatory host factor in HCV replication. Down-regulation of PI4KA appears to be reasonably tolerated by cultured cell models and results.
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表达系统:
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阳性对照:
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保存温度:
-20°C
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运输温度:
AMBIENT
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细胞定位:
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预期分子量:
603.5
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产品形式:
solid
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存储溶液:
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有效期:
Stable for at least 2 years after receipt when stored at -20°C.
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产地:
瑞士
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纯度:
>95%
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Accession #:
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CAS号:
1402345-92-9
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分子式:
C27H18F5N5O4S
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溶解度:
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PubChem CID: