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产品名称:
Tangeretin
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别名:
4',5,6,7,8-Pentamethoxyflavone; NSC 53909; NSC 618905; Ponkanetin; 5,6,7,8-Tetramethoxy-2-(4-methoxyphenyl)-4H-1-benzopyran-4-one
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产品描述:
Tangeritin is a polymethoxylated flavone isolated from peels of citrus fruits with antiproliferative and antioxidant properties. It inhibits signaling in cancer cells, reducing ERK phosphorylation and growth of estradiol-stimulated T47D breast cancer cells and blocking p38 MAPK, JNK, and Akt activation in interleukin-1beta-stimulated human lung carcinoma A549 cells. It is described to block cell cycle progression at G1 and induce apoptosis. Shows anti-inflammatory, osteoprotective and neuroprotective effects. Tangeritin activates the pregnane X receptor, inducing MDR1 expression in human colonic LS180 cancer cells. Shown to be a Notch-1 inhibitor. Tangeretin stimulates glucose uptake via regulation of AMPK signaling pathways and has been shown to antagonize ABCB1-mediated multidrug resistance.
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反应种属:
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宿主来源:
Isolated from plant source.
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表达系统:
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阳性对照:
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保存温度:
+20°C
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运输温度:
Ambient
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细胞定位:
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预期分子量:
372.37
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产品形式:
solid
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存储溶液:
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有效期:
Stable for at least 2 years after receipt when stored at RT.
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产地:
瑞士
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纯度:
>98% (HPLC)
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Accession #:
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CAS号:
481-53-8
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分子式:
C20H20O7
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溶解度:
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PubChem CID: