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产品名称:
Alpelisib
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别名:
(2S)-N1-[4-Methyl-5-[2-(2,2,2-trifluoro-1,1-dimethylethyl)-4-pyridinyl]-2-thiazolyl]-1,2-pyrrolidinedicarboxamide; BYL719; NVP-BYL719
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产品描述:
Selective PI3Kalpha inhibitor with IC50 of 5nM. Has minimal effect on other PI3K isoforms. Exhibits favorable pharmacokinetics and excellent oral bioavailability in animal models. In xenografts using nude mice, it showed dose-dependent effects of tumour inhibition. In a phase Ib study, it showed synergistic anti-tumor activity with endocrine therapy against ER+/PIK3CA mutated breast cancer cells.
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表达系统:
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阳性对照:
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保存温度:
-20°C
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运输温度:
AMBIENT
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细胞定位:
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预期分子量:
441.5
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产品形式:
solid
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存储溶液:
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有效期:
Stable for at least 2 years after receipt when stored at -20°C.
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产地:
瑞士
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纯度:
>95%
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Accession #:
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CAS号:
1217486-61-7
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分子式:
C19H22F3N5O2S
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溶解度:
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PubChem CID: