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产品名称:
Cyclopamine
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别名:
11-Deoxyjervine; 11-Deoxojervine; HSDB 3505
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产品描述:
Cell permeable steroidal alkaloid. Specific sonic hedgehog (Shh) signaling pathway inhibitor. Directly interacts/inhibits Smo (smoothened) [1-4]. Teratogenic [1] and antitumor compound. Inhibits tumor cell growth and progression. Shows selective activity against Shh-dependent tumors [5-11]. Blocks abnormal cell growth associated with oncogenic mutations of Ptch and Smo in fibroblasts [2]. Arrests cell cycle at G0/G1 [6]. Apoptosis inducer [8].
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反应种属:
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宿主来源:
Isolated from Veratrum californicum.
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实验应用:
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同种型:
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产品浓度:
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表达系统:
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阳性对照:
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保存温度:
-20°C
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运输温度:
Ambient
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细胞定位:
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预期分子量:
411.6
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产品形式:
solid
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存储溶液:
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有效期:
Stable for at least 2 years after receipt when stored at -20°C. Store solutions at -20°C in the dark.
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产地:
瑞士
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纯度:
>98%
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Accession #:
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CAS号:
4449-51-8
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分子式:
C27H41NO2
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溶解度:
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PubChem CID: