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产品名称:
K-252c
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别名:
Staurosporine aglycone; Staurosporinone; Antibiotic K252c; 6,7,12,13-Tetrahydro-5H-indolo[2,3-a]pyrrolo[3,4-c]carbazol-5-one
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产品描述:
Indolocarbazole alkaloid antibiotic. [1]. Potent cell permeable reversible and ATP-competitive PKC (protein kinase C) inhibitor with 10-fold selectivity over PKA (protein kinase A) [1-5]. Anticancer compound. Cytotoxic againt various cancer cell lines [6, 9,11]. Apoptosis inducer [11]. Antiviral compound against GCV-sensitive and -resistant strains of human cytomegalovirus (HCMV) [7]. LACTB (beta-lactamase), malate dehydrogenase (MDH2, MDHC, MDH1B, ME1. ME2, ME3) and chymotrypsin inhibitor [8]. Inhibits mixed lineage kinase (MLK) [10].
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反应种属:
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宿主来源:
Isolated from Streptomyces longisporoflavus.
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实验应用:
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同种型:
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产品浓度:
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表达系统:
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阳性对照:
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保存温度:
-20°C
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运输温度:
Ambient
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细胞定位:
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预期分子量:
311.4
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产品形式:
solid
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存储溶液:
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有效期:
Stable for at least 2 years after receipt when stored at -20°C. Store solutions at -20°C in the dark. Stock solutions are stable for at least 3 months when stored at -20°C.
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产地:
瑞士
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纯度:
>97% (HPLC)
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Accession #:
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CAS号:
85753-43-1
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分子式:
C20H13N3O
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溶解度:
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PubChem CID: