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2-Trifluoromethyl-2'-methoxychalcone
品牌: Cayman
产品货号: 11881-100 mg
规格: 100 mg

报价:
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数量: - +
产品详情
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  • 产品名称:
    2-Trifluoromethyl-2'-methoxychalcone
  • 别名:
  • 产品描述:
    Nrf2 activation is central to cytoprotective gene expression against oxidative and/or electrophilic stress.{17702} Unless activated by inflammatory, environmental, or oxidative stressors, Nrf2 is sequestered in the cytoplasm by its repressor, Keap1.{16386} Because of its protective capabilities, small molecules that activate Nrf2 signaling are being examined as potential anti-cancer or anti-inflammatory agents.{20661} 2-Trifluoromethyl-2'-methoxychalcone is a potent activator of Nrf2, both in vitro and in mice.{21374} Human bronchial epithelial cells treated with 10 μM 2-trifluoromethyl-2'-methoxychalcone showed a marked increase in the expression of the Nrf2-regulated antioxidant genes, GCLM and NQO1. Furthermore, treatment of mice with 50 mg/kg 2-trifluoromethyl-2’-methoxychalcone leads to a 4.5- and 4.6-fold increase in the expression of GCLM and NQO1, respectively, in the small intestine.{21374}
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  • 阳性对照:
  • 保存温度:
    -20
  • 运输温度:
    -20
  • 细胞定位:
  • 预期分子量:
    306.3
  • 产品形式:
    A solution in methyl acetate
  • 存储溶液:
  • 有效期:
    730
  • 产地:
    美国
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  • 纯度:
    ≥98%
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  • CAS号:
    1309371-03-6
  • 分子式:
    C17H13F3O2
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