产品描述:
PF-04937319 is an activator of glucokinase (EC50s = 174, 407, and 269 nM for the recombinant human, rat, and dog enzymes, respectively).{58003} It increases glucose-induced insulin secretion in isolated rat islets when used at concentrations of 4 and 12 µM.{58004} PF-04937319 (3-100 mg/kg) reduces postprandial plasma glucose levels in rats.