产品描述:
SR 717 is an agonist of stimulator of interferon genes (STING; EC50 = 2.1 µM in a reporter assay).{61199} It is selective for STING over a panel of 468 kinases. SR 717 (30 mg/kg, i.p.) increases plasma IFN-β and IL-6 levels in mice. It also increases the intratumor frequency of CD69+CD8+ T cells, reduces tumor growth, and increases survival in a B16/F10 murine melanoma model.