货号:10009762 | 规格:1 ea | 目录价:¥6736 |
产品详情
产品名称:
Progesterone Receptor (Phospho-Ser190) Monoclonal Antibody (Clone 1154)
产品描述:
There is accumulating evidence to suggest that progesterone plays an essential role in the regulation of growth and differentiation of mammary glands and thus may play a key role in breast cancer.{14655} The biological response to progesterone is mediated by two distinct forms of the human progesterone receptor (PR-A and PR-B forms). In most cell contexts, the B form functions as a transcriptional activator, whereas the A form functions as a transcriptional inhibitor of steroid hormones.{14653,14656} Recently it has been demonstrated that there is differential hormone dependent regulation of the phosphorylation of the A and B forms of the receptor.{14654} Treatment of T47D breast cancer cells with progestin agonist increases the phosphorylation of Ser190 and Ser294 with different kinetics. These phosphorylation events may differentially affect the transcriptional activity of the receptor.
宿主来源:
Mouse
实验应用:
IHC, WB
同种型:
IgG1
免疫原:
Phosphopeptide from amino acid residues surrounding the phospho-Ser294 of human progesterone receptor
克隆号:
1154
保存温度:
-20
运输温度:
-20
产品形式:
100 µl of protein G-affinity purified monoclonal antibody
有效期:
365
来源:
Animal/Mouse
上一个:Prion Protein Monoclonal Antibody (Clone BAR 236)
下一个:Progesterone Receptor (Phospho-Ser294) Monoclonal Antibody
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