Renin Monoclonal Antibody (Clone 3G10)-单抗-ELISA_抗体_蛋白_核苷酸

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Renin Monoclonal Antibody (Clone 3G10)

品牌：Cayman

官网链接

说明书

折扣/货期

货号：17624

规格：200 µg

目录价：￥4410

产品详情

产品名称:

Renin Monoclonal Antibody (Clone 3G10)

别名:

Angiotensinogenase

产品描述:

Renin is an aspartyl protease glycoprotein, a member of the aspartic acid protease family, and a hormone.{57726} It is a single-chain polypeptide in which the N- and C-terminal portions contain an aspartate residue responsible for its catalytic activity. It is formed from prorenin, a zymogen found primarily in the juxtaglomerular cells in the kidney, by proteolytic removal of its autoinhibitory domain.{12970},{57727} Renin catalyzes the conversion of angiotensinogen to angiotensin I, which is the first and rate-limiting step of the renin-angiotensin system (RAS) responsible for regulating blood pressure.{57727} When blood pressure is low, renin secretion is increased and the RAS is activated, which increases arterial vasoconstriction and sodium resorption to maintain blood pressure at homeostatic levels.{13007} Deletion or substitution of the leucine in position 16 of REN, the gene encoding renin, that reduce or eliminate renin biosynthesis are associated with multiple inflammatory diseases, including chronic kidney failure and early-onset hyperuricemia.{57728} Cayman's Renin Monoclonal Antibody (Clone 3G10) can be used for immunoprecipitation (IP) and Western blot applications.

宿主来源:

Mouse

实验应用:

IP, WB

同种型:

IgG2b

免疫原:

Recombinant human renin

克隆号:

3G10

保存温度:

-20