货号:17624 | 规格:200 µg | 目录价:¥4410 |
产品详情
产品名称:
Renin Monoclonal Antibody (Clone 3G10)
别名:
Angiotensinogenase
产品描述:
Renin is an aspartyl protease glycoprotein, a member of the aspartic acid protease family, and a hormone.{57726} It is a single-chain polypeptide in which the N- and C-terminal portions contain an aspartate residue responsible for its catalytic activity. It is formed from prorenin, a zymogen found primarily in the juxtaglomerular cells in the kidney, by proteolytic removal of its autoinhibitory domain.{12970},{57727} Renin catalyzes the conversion of angiotensinogen to angiotensin I, which is the first and rate-limiting step of the renin-angiotensin system (RAS) responsible for regulating blood pressure.{57727} When blood pressure is low, renin secretion is increased and the RAS is activated, which increases arterial vasoconstriction and sodium resorption to maintain blood pressure at homeostatic levels.{13007} Deletion or substitution of the leucine in position 16 of REN, the gene encoding renin, that reduce or eliminate renin biosynthesis are associated with multiple inflammatory diseases, including chronic kidney failure and early-onset hyperuricemia.{57728} Cayman's Renin Monoclonal Antibody (Clone 3G10) can be used for immunoprecipitation (IP) and Western blot applications.
宿主来源:
Mouse
实验应用:
IP, WB
同种型:
IgG2b
免疫原:
Recombinant human renin
克隆号:
3G10
保存温度:
-20
运输温度:
-20
产品形式:
100 µl caprylic acid/ammonium sulfate-purified monoclonal antibody
有效期:
1095
上一个:Citrullinated Fibrinogen Monoclonal Antibody (Clone 10E9.3)
下一个:STING Monoclonal Antibody (Clone 2C8)
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