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折扣/货期| 货号：10348 | 规格：25 µg | 目录价：￥5964 |
产品详情
产品名称:
Sphingosine Kinase 1 (human, recombinant)
别名:
SK1|SPHK1
产品描述:
Sphingosine kinase (SPHK) is an important enzyme in the sphingolipid metabolic pathway. SPHKs phosphorylate D-erythro-sphingosine to yield sphingosine-1-phosphate (S1P). To date two isoforms of SPHK, SPHK1 and SPHK2, have been identified & characterized from mammalian cells.{14483} Among them, SPHK1 has been implicated to play a role in signaling pathways in mast cells and in TNF-α-triggered responses of fibroblasts and epithelial cells. Recent findings also indicate that SPHK1 mRNA levels are increased in a variety of human tumors. Brain tumors with high SPHK1 expression correlated with poor survival of patients and high expression of SPHK1 appears to be an oncogenic event required for erythroleukaemic progression.{14534,14535} Thus SPHK is a potential therapeutic target for the control of cancer and inflammation.{14534,14535}
保存温度:
-80
运输温度:
-80
产品形式:
25 mM HEPES, pH 8.0, with 150 mM sodium chloride, 3 mM DTT, 0.05% polysorbate 20, and 25% glycerol
有效期:
365
纯度:
≥80% estimated by SDS-PAGE
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