STING (C-Term) Monoclonal Antibody (Clone 1B10)-单抗-ELISA_抗体_蛋白_核苷酸

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STING (C-Term) Monoclonal Antibody (Clone 1B10)

品牌：Cayman

官网链接

说明书

折扣/货期

货号：25923

规格：100 µg

目录价：￥5096

产品详情

产品名称:

STING (C-Term) Monoclonal Antibody (Clone 1B10)

别名:

产品描述:

Stimulator of interferon genes (STING) is a component of the innate immune response that binds to cyclic dinucleotides (CDNs), which are bacterial second messengers, leading to activation of NF-κB and transcription of immunomodulatory genes, including type I interferon (IFN).{22400,22401,24611,24607} The C-terminal region of STING binds to CDNs, such as cyclic di-GMP (c-di-GMP; Item No. 17144) in the cytoplasm at a ratio of two STING molecules to one c-di-GMP.{24607,39991} Mutations in the C-terminal region modify the activity of STING in a variety of ways.{24607} Certain mutations, such as the mutation found in the Goldenticket mouse strain, I199N, prevent STING from binding to CDNs and from inducing an IFN response. However, other mutations in the C-terminal region allow STING to bind c-di-GMP but not induce IFN, hyperinduce IFN without binding c-di-GMP, or induce IFN only when overexpressed and without binding c-di-GMP. STING inhibition has the potential to be beneficial for the treatment of autoimmune diseases that are associated with uncontrolled activation of the STING pathway, while activation of STING can lead to an adaptive immune response that reduces tumor growth in animal models.{39992,41598,38806,39993} Cayman’s STING (C-Term) Monoclonal Antibody (Clone 1B10) can be used for ELISA, IHC, and WB applications. The antibody recognizes the C-terminal region of STING at 42 kDa from human samples.

宿主来源:

Mouse

实验应用:

ELISA, IHC, and WB

同种型:

IgG1

免疫原:

Synthetic peptide from the C-terminus (AA 351-379) of human STING protein

克隆号:

1B10

保存温度:

-20