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折扣/货期| 货号：11520 | 规格：500 µg | 目录价：￥5544 |
产品详情
产品名称:
Thioredoxin 1 (C61S/C72S mutant; human, recombinant)
别名:
Trx1|TrxA|Txn1
产品描述:
Thioredoxin 1 (Trx1) is a thiol-disulfide oxidoreductase and part of the antioxidant thioredoxin system that is involved in the maintenance of cellular thiol redox homeostasis.{57135,57136,57138} It is ubiquitously expressed, localizes primarily to the cytoplasm with some nuclear localization, and is upregulated in and released from cells under conditions of oxidative stress.{57135,57137,57136} Trx1 contains two active site cysteine residues at positions 32 and 35 with additional cysteines at positions 62, 69, and 73.{57136} During the catalytic cycle, the active site cysteines are oxidized to a disulfide upon reduction of oxidized protein disulfide substrates and are subsequently restored to their reduced state by thioredoxin reductase (TrxR) and NADPH.{57135,57136} In the human recombinant enzyme, the initiating methionine is removed, and thus the positions of the amino acids are counted without the N-terminal methionine.{61516} Cysteine-to-serine substitutions at Cys61 (C61S) and Cys72 (C72S) in Trx1 (Trx1C61S/C72S) prevent oxidation-induced inhibition of protein disulfide reductase activity in Trx1.{20447} Cayman's Thioredoxin 1 (C61S/C72S mutant; human, recombinant) protein can be used for enzyme activity assays.
保存温度:
4
运输温度:
4
产品形式:
Lyophilized in 50 mM Tris-HCl, pH 7.5, with 1 mM EDTA
有效期:
180
纯度:
≥85% estimated by SDS-PAGE
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