货号:10322 | 规格:1 ea (400 µg) | 目录价:¥4410 |
产品详情
产品名称:
TIM-4 Monoclonal Antibody
别名:
T cell Immunoglobulin and Mucin Domain-containing 4|T Cell Immunoglobulin Mucin Receptor 4|T cell Membrane Protein 4|TIMD-4
产品描述:
TIM-4 is a type I transmembrane protein and member of the T cell immunoglobulin and mucin domain-containing (TIM) family of immunoregulatory proteins.{21964} It is composed of an N-terminal immunoglobulin variable (IgV) domain that binds to phosphatidylserine, as well as a mucin stalk, which contains O- and N-linked glycosylation sites, a transmembrane domain, and a C-terminal cytoplasmic tail, which lacks a tyrosine phosphorylation site, unlike TIM-1 and TIM-3.{15136,21964] TIM-4 is expressed in antigen-presenting cells (APCs) such as dendritic cells and macrophages and binds to TIM-1 on activated T cells.{21967} It is mainly involved in phagocytosis of apoptotic cells via recognition of phosphatidylserine, but also plays a role in T cell proliferation and survival, viral entry, and antitumor immunity.{15136,29982,67258,67259} TIM-4 targeting antibodies prevent HIV-1 entry into host cells in vitro and enhance the efficacy of anticancer vaccines in a murine melanoma model.{67258,67259} SNPs in TIMD4 are associated with increased susceptibility of asthma in children.{21966} Cayman's TIM-4 Monoclonal Antibody can be used for flow cytometry (FC) and immunocytochemistry (ICC) applications.
宿主来源:
Armenian hamster
实验应用:
FC, ICC
免疫原:
Mouse peritoneal cell TIM-4
保存温度:
-20
运输温度:
-20
产品形式:
400 µg of protein A-purified monoclonal antibody
有效期:
1095
上一个:Prostaglandin I Synthase Monoclonal Antibody (Clone 3C8)
下一个:CD25/Interleukin-2Rα Monoclonal Antibody (PE) (Clone 143-13)
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