TIM-4 Monoclonal Antibody-单抗-ELISA_抗体_蛋白_核苷酸_试剂盒-深圳欣博盛生物科技有限公司

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TIM-4 Monoclonal Antibody

品牌：Cayman

官网链接

说明书

折扣/货期

货号：10322

规格：1 ea (400 µg)

目录价：￥4410

产品详情

产品名称:

TIM-4 Monoclonal Antibody

别名:

T cell Immunoglobulin and Mucin Domain-containing 4|T Cell Immunoglobulin Mucin Receptor 4|T cell Membrane Protein 4|TIMD-4

产品描述:

TIM-4 is a type I transmembrane protein and member of the T cell immunoglobulin and mucin domain-containing (TIM) family of immunoregulatory proteins.{21964} It is composed of an N-terminal immunoglobulin variable (IgV) domain that binds to phosphatidylserine, as well as a mucin stalk, which contains O- and N-linked glycosylation sites, a transmembrane domain, and a C-terminal cytoplasmic tail, which lacks a tyrosine phosphorylation site, unlike TIM-1 and TIM-3.{15136,21964] TIM-4 is expressed in antigen-presenting cells (APCs) such as dendritic cells and macrophages and binds to TIM-1 on activated T cells.{21967} It is mainly involved in phagocytosis of apoptotic cells via recognition of phosphatidylserine, but also plays a role in T cell proliferation and survival, viral entry, and antitumor immunity.{15136,29982,67258,67259} TIM-4 targeting antibodies prevent HIV-1 entry into host cells in vitro and enhance the efficacy of anticancer vaccines in a murine melanoma model.{67258,67259} SNPs in TIMD4 are associated with increased susceptibility of asthma in children.{21966} Cayman's TIM-4 Monoclonal Antibody can be used for flow cytometry (FC) and immunocytochemistry (ICC) applications.

宿主来源:

Armenian hamster

实验应用:

FC, ICC

免疫原:

Mouse peritoneal cell TIM-4

保存温度:

-20

运输温度:

-20

产品形式:

400 µg of protein A-purified monoclonal antibody