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折扣/货期| 货号：10783 | 规格：100 µg | 目录价：￥6902 |
产品详情
产品名称:
TIP60 (human, recombinant)
别名:
cPLA(2) Interacting Protein|Esa1|Histone acetyltransferase KAT5|HIV-1 Tat Interacting Protein 60 kDa|Hs.6364|HTATIP|KAT5|PLIP
产品描述:
TIP60 is a member of the MYST family of lysine acetyl transferases. It has been shown to acetylate histones, p53, and the Ataxia Telangiectasia Mutant (ATM) protein kinase.{20520} As a component of the TIP60-p400 complex, TIP60 acetylates transcription repressors in order to inhibit gene transcription.{20521} In complexes without p400, TIP60 is part of a chromatin remodeling complex which plays an important role in double-stranded DNA break repair. Acetylation of histone γH2AX allows formation of the γH2AX repair foci, and acetylation of ATM is one of the early steps in double-stranded DNA break repair. Furthermore, TIP60 is bound by the cytoplasmic tail of β-amyloid precursor protein which drives gene transcription, apoptosis, and potentially a role in Alzheimer’s disease pathogenesis.{20522}
保存温度:
-80
运输温度:
-80
产品形式:
50 mM Tris-HCl, pH 7.5, with 300 mM sodium chloride and 10% glycerol
有效期:
180
纯度:
≥50%
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