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折扣/货期| 货号：33745 | 规格：10 µg | 目录价：￥7038 |
产品详情
产品名称:
TYK2 (human, recombinant)
别名:
JTK1|Non-receptor Tyrosine Protein Kinase|Tyrosine Kinase 2
产品描述:
Tyrosine kinase 2 (TYK2) is a member of the JAK family of non-receptor tyrosine kinases that has a key role in cytokine signaling.{62097,62098} It is composed of an N-terminal FERM homology domain, which mediates protein-protein interactions, a Src-homology 2 (SH2) domain, a catalytically inactive pseudokinase domain, and a catalytically active C-terminal kinase domain.{62097} TYK2 is expressed by a variety of immune cells, including T and B cells, dendritic cells, mast cells, and macrophages, where it associates with numerous cytokine receptor chains, including IFNARI, IL-12Rβ1, IL-10R2, gp130, and IL-13Rα1, to mediate STAT-dependent cytokine signaling.{62098,62097,62099} TYK2 is activated by its phosphorylation, which is induced by ligand-bound cytokine receptors via JAK1 or JAK2-mediated transactivation, and is inhibited by suppressor of cytokine signaling (SOCS) proteins.{62099} TYK2 has roles in numerous immunological processes, including inflammatory and autoimmune diseases, pathogen defense, and allergy, as well as tumor surveillance and cancer.{62097,62099} TYK2 SNPs have been identified in patients with acute myeloid leukemia, and TYK2 polymorphisms have been associated with systemic lupus erythematosus (SLE) and multiple sclerosis in humans.{62097} Cayman's TYK2 (human, recombinant) protein can be used for enzyme activity assays.
保存温度:
-80
运输温度:
-80
产品形式:
45 mM Tris, pH 8.0, with 125 mM sodium chloride, 2.4 mM potassium chloride, 0.045% Tween 20, 50-500 mM imidazole, and 10% glycerol
有效期:
180
纯度:
≥90% estimated by SDS-PAGE
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