DNA损伤有多种检测方法，其中Stressmarq的DNA损伤检测试剂盒（SKT-120）主要是通过竞争法ELISA检测2 8-羟基脱氧鸟苷含量确定DNA损伤的情况。该DNA损伤检测试剂盒可以检测的样本类型包括：细胞裂解液，血浆，尿液。该试剂盒已被85篇文献引用，产品质量稳定且精准。
DNA损伤检测试剂盒（SKT-120）信息：
供应商 | 产品编号 | 产品名称 | 规格 |
Stressmarq | SKT-120-96S | DNA Damage (8-OHdG) ELISA Kit | 96 well |
Stressmarq | SKT-120-480S | DNA Damage (8-OHdG) ELISA Kit | 5 x 96 well |
Stressmarq DNA损伤检测试剂盒（SKT-120）特点：
1. 检测时间更短 – 新试剂盒的检测时间由原来的18小时缩短到仅仅1个小时。
2. 稳定性更强 – 旧款试剂盒的乙酰胆碱酯酶和 Ellmans’ 试剂盒被替换成 HRP 以及 TMB，增强了稳定性，无需储存在 -20°C。
3. 简化的实验步骤 – 直接标记的一抗以及其他组件的改进减少了所需试剂，从而简化了实验步骤。
4. 更广的检测范围 – 新试剂盒检测范围增加到 0.94 - 60 ng/ml ，这可以减少稀释步骤并且该范围可能更适宜生物样品的读数 。
2021年使用Stressmarq DNA损伤检测试剂盒（SKT-120）发表的文献
● High throughput data-based, toxicity pathway-oriented development of a quantitative adverse outcome pathway network linking AHR activation to lung damages
Jin, Y. et al (2021) J Hazard Mater. 425:128041
PubMed ID: 34906874 Reactivity Human Applications: Bronchial epithelial cell line 16HBE
● Effect of Low-Dose Gamma Lipoic Acid on High- Radiation-Dose Induced Radiation and Rat Brain Injuries.
Abdel-Aziz, N., Elkady, A., Elgazzar, E. (2021) Dose Response 2021:1–13
PubMed ID: 34759786 Reactivity Rat Applications: Brain tissue
● A novel inactivated whole-cell Pseudomonas aeruginosa vaccine that acts through the cGAS-STING pathway.
Ma, C. et al. (2021) Signal Transduct Target Ther (2021) 6:353
PubMed ID: 34593766 Reactivity P. aeruginosa
● Systemic Profiles of microRNAs, Redox Balance, and Inflammation in Lung Cancer Patients: Influence of COPD.
Qin, L. et al. (2021) Biomedicines 2021, 9(10), 1347
PubMed ID: 34680465 Reactivity Human Applications: Plasma
● 8-Formylophiopogonanone B induces ROS-mediated apoptosis in nasopharyngeal carcinoma CNE-1 cells
Zhang, Y. et al. (2021) Toxicol. Res. Online ahead of print.
PubMed ID: N/A
● Experimental evidence that social instability influences rank-specific patterns in oxidative stress in a cichlid fish.
Border, S.E. et al. (2021) J Exp Biol. jeb.237172
PubMed ID: 34495308 Reactivity Fish
● Effects of prenatal stress deficiency in C57BL/6 mice on and/or forebrain ATRX cellular metabolism, DNA damage, ATM promoter methylation and gene expression.
Maillet, H. M. (2021) Dalhousie University Masters Thesis
PubMed ID: N/A Reactivity Mouse Applications: pre frontal cortex, hippocampus and cerebellum
● Evaluating the Effects of Commiphora Molmol (Myrrh) Against Oxidative DNA Damage in Human Lymphocytes.
Daradka, H. et al. (2021) IJPSR 12(6): 3143-3149
PubMed ID: N/A Reactivity Human Applications: Lymphocytes
● Curcumin Modulates Nitrosative Stress, Inflammation, and DNA Damage and Protects against Ochratoxin A-Induced Hepatotoxicity and Nephrotoxicity in Rats.
Longobardi, C. et al. (2021) Antioxidants 10(8), 1239
PubMed ID: 34439487 Reactivity Rat Applications: Urine
● Oxidative Stress in Cerebrospinal Fluid During Treatment in Childhood Acute Lymphoblastic Leukemia.
Dewan, P. et al. (2021) Cureus 13(6): e15997
PubMed ID: 34336488 Reactivity Human Applications: Cerebrospinal Fluid
● Changes in Urinary Biomarkers of Organ Damage, Inflammation, Oxidative Stress, and Bone Turnover Following a 3000-m Time Trial
Tominaga, T. et al. (2021) Antioxidants 2021, 10, 79
PubMed ID: 33435279 Reactivity Human Applications: Urine
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