神经节苷脂是酸性鞘糖脂，其在细胞质膜的外部小叶中形成脂筏，特别是在中枢神经系统的神经元细胞中。它们参与细胞增殖、分化、粘附、信号转导、细胞间相互作用、肿瘤发生和转移，神经节苷脂的积累与几种疾病有关。神经节苷脂GD1b可作为细菌毒素受体（破伤风、肉毒杆菌），在胶质瘤和星形细胞瘤中数量高，它可调节蛋白激酶活性。在体内和体外，它与内酯结构处于平衡状态。
产品详情
别名：GD1b . 2Na; Disialoganglioside GD1b . 2Na
来源：Isolated from bovine brain.
分子式：C84H146N4O39 . 2Na
分子量：1836.1 . 46.0 (calculated on sphingosine
C18:1 and stearic acid)
CAS号：19553-76-5
纯度：≥98% (TLC)
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部分产品文献
1.Role of membrane gangliosides in the binding and action of bacterial toxins: P.H. Fishman; J. Membr. Biol. 69, 85 (1982)
2.Natural occurrence of ganglioside lactones. Isolation and characterization of GD1b inner ester from adult human brain: L. Riboni, et al.; J. Biol. Chem. 261, 8514 (1986)
3.Exogenous gangliosides GD1b and GD1b-lactone, stably associated to rat brain P2 subcellular fraction, modulate differently the process of protein phosphorylation: R. Bassi, et al.; J. Neurochem. 57, 1207 (1991)
4.Immunohistochemical staining for ganglioside GD1b as a diagnostic and prognostic marker for primary human brain tumors: T.C. Comas, et al.; Neuro Oncol. 1, 261 (1999)
5.Dynamic and structural properties of sphingolipids as driving force to the formation of membrane domains: S. Sonnino, et al.; Chem. Rev. 106, 2111 (2006)
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