精氨酸加压素 (AVP) 是在大脑下丘脑中合成并储存在垂体中的一种肽激素。AVP是一种抗利尿剂，可通过作用于肾小管以增加液体的重吸收和血容量来调节血压。AVP升高和高血压、心力衰竭相关。AVP通过与一组特定的包含七个跨膜结构域的G蛋白偶联受体(GPCR)结合而起作用，GPCR 分为三组：V1a (V1)、V1b (V3) 和 V2。V1b 受体刺激垂体前叶释放促肾上腺皮质激素 (ACTH)，但也可能参与下丘脑释放促肾上腺皮质激素释放激素 (CRH)。V1b 受体通过 Gq/11α亚基偶联、激活磷脂酶 C 和通过磷酸肌醇第二信使释放细胞内Ca 2+发出信号。V1b受体过表达是促肾上腺皮质激素分泌腺瘤的常见标志物。肾脏集合管中的V2受体刺激腺苷酸环化酶活性，通过水通道蛋白通道调节水的重吸收。
● 高灵敏度，可检测到低至2.84 pg/ml精氨酸加压素
● 特异性高，与催产素几乎不反应
● 简单易用的液体颜色编码试剂可减少错误
● 超越半定量Western blot分析的全定量检测
Enzo品牌Arg8-Vasopressin ELISA kit是一种比色竞争法酶免疫检测试剂盒，可在隔夜 + 1 小时内得出结果。在 450 nm 处读取吸光度。
产品信息
产品货号 | ADI-900-017A |
产品名称 | Arg8-Vasopressin ELISA kit（精氨酸加压素ELISA试剂盒） |
规格 | 96 wells |
其他名称 | AVP |
灵敏度 | 2.84 pg/ml |
检测范围 | 4.10-1,000 pg/ml |
检测时间 | Overnight + 1 hour |
样本种属 | Species independent |
样本类型 | serum, plasma, and tissue culture media. |
保存温度 | Store all components at +4°C, except standard at -20°C. |
试剂盒组分 | GxR IgG Microtiter plate, Conjugate, Antibody, Assay buffer, Wash buffer concentrate, Standard, SA-HRP, TMB Substrate, Stop solution |
部分产品文献引用
1. Contrasting central and systemic effects of arginine-vasopressin on urinary marking behavior as a social signal in male mice: Y. Higuchi, et al.; Horm. Behav. 141, 105128 (2022)
2. Evaluating the neuropeptide-social cognition link in ageing: the mediating role of basic cognitive skills: R. Polk, et al.; Philos. Trans. R. Soc. Lond. B Biol. Sci. 29, 377 (2022)
3. Persistent autism-relevant behavioral phenotype and social neuropeptide alterations in female mice offspring induced by maternal transfer of PBDE congeners in the commercial mixture DE-71: E.V. Kozlova, et al.; Arch. Toxicol. 96, 335 (2022)
4. Renal function during sevoflurane or total intravenous propofol anaesthesia: a single-centre parallel randomised controlled study: S. Franzen, et al.; Br. J. Anaesth. 1289, 838 (2022)
5. Transcription factor Creb3l1 maintains proteostasis in neuroendocrine cells: M. Greenwood, et al.; Mol. Metab. 63, 101542 (2022)
6. Activation of Orexin 1 Receptors in the Paraventricular Nucleus Contributes to the Development of Deoxycorticosterone Acetate-Salt Hypertension Through Regulation of Vasopressin: J. Bigalke, et al.; Front. Physiol. 12, 641331 (2021)
7. Autism-associated biomarkers: test–retest reliability and relationship to quantitative social trait variation in rhesus monkeys: O. Oztan, et al.; Mol. Autism 12, 13229 (2021)
8. Circadian Clock Component BMAL1 in the Paraventricular Nucleus Regulates Glucose Metabolism: M. Nakata, et al.; Nutrients 13, 4487 (2021)
9.Differential roles of VPS and RAAS in water homeostasis and a risk for kidney dysfunction in rats undergoing rapid fasting/dehydration with regular exercise: K. Hasegawa, et al.; Physiol. Rep. 9, e14670 (2021), Application(s): ELISA using rat plasma
10. Importance of the renal ion channel TRPM6 in the circadian secretion of renin to raise blood pressure: Y. Funato, et al.; Nat. Commun. 12, 3683 (2021), Application(s): ELISA using mouse plasma
Arg8-Vasopressin ELISA kit - ADI-900-017A - Enzo Life Sciences
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