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BioXcell新品推荐——InVivoMAb anti-rat/mouse CD71 (TfR1)单克隆抗体

2021-04-29
浏览次数: 73

BioXcell新品推荐——InVivoMAb anti-rat/mouse CD71 (TfR1)单克隆抗体


InVivoMAb anti-rat/mouse CD71 (TfR1)

Useful for targeted drug delivery to the brain

 

研发背景: 

OX-26单克隆抗体可识别大鼠的CD71蛋白,CD71蛋白也被称为转铁蛋白受体蛋白1TfR1)。据报道,该抗体OX-26也与小鼠CD71发生交叉反应。CD71是一种170-180kdaII型同型二聚体跨膜糖蛋白,其表达于增殖细胞、网状细胞和类红细胞前体等细胞的表面。

 

CD71在调节细胞增殖中起着重要作用,它是通过细胞内吞作用将铁从转铁蛋白转运到细胞内的。有研究表明,CD71在恶性肿瘤细胞中高水平表达,其表达与肿瘤的进展有关。这种在恶性细胞上的高表达,加上CD71的内化能力以及铁对癌细胞增殖的必要性,会使转铁蛋白受体成为一个有吸引力的靶点,可用于将药物输送到恶性细胞。OX-26CD71的胞外结构域结合后,通过内源性转铁蛋白转运系统进入血脑屏障(Blood-Brain BarrierBBB)。在这一机制下,OX-26抗体常被用于在实验性大鼠模型中通过BBB转运结合药物。

 

 抗体的应用

◎ 脑部的靶向给药

◎ 冰冻切片的免疫组化实验

◎ 流式细胞术

 

 一如既往,BioXcell抗体是专为体内使用而制备的,具有以下特点:

◎ 95%纯度

◎ 超低内毒素水平

◎ 不含防腐剂、稳定剂和载体蛋白

 

 产品信息:  

产品货号

BE0331

产品名称

InVivoMAb anti-rat/mouse CD71 (TfR1)

规格

1mg5mg25mg50mg100mg

克隆号

OX-26

同种型(Isotype)

Mouse IgG2a, κ

免疫原(Immunogen)

PHA-activated PVG rat lymph node cells

成分(Formulation)

PBS, pH 7.0

Contains no stabilizers or preservatives

内毒素(Endotoxin)

<2EU/mg (<0.002EU/μg)

Determined by LAL gel clotting assay

纯度(Purity)

>95%

Determined by SDS-PAGE

无菌(Sterility)

0.2 μM filtered

生产(Production)

Purified from tissue culture supernatant in an animal free facility

纯化(Purification)

Protein A

保存(Storage)

The antibody solution should be stored at the stock concentration at 4°C. Do not freeze.

应用(Reported Applications)

Targeted drug delivery to the brain

Immunohistochemistry (frozen)

Flow cytometry

 

 Application References:  

Amani, H., et al. (2019). 'Selenium nanoparticles for targeted stroke therapy through modulation of inflammatory and metabolic signaling.' Sci Rep 9(1): 6044. 

Tang, X., et al. (2015). 'Anti-transferrin receptor-modified amphotericin B-loaded PLA-PEG nanoparticles cure Candidal meningitis and reduce drug toxicity.' Int J Nanomedicine 10: 6227-6241 

Yue, J., et al. (2012). 'Fluorescence-labeled immunomicelles: preparation, in vivo biodistribution, and ability to cross the blood-brain barrier.' Macromol Biosci 12(9): 1209-1219. 

Fabriek, B. O., et al. (2007). 'The macrophage CD163 surface glycoprotein is an erythroblast adhesion receptor.' Blood 109(12): 5223-5229. 

Jimenez, E., et al. (2002). 'Rat peripheral CD4+CD8+ T lymphocytes are partially immunocompetent thymus-derived cells that undergo post-thymic maturation to become functionally mature CD4+ T lymphocytes.' J Immunol 168(10): 5005-5013.




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