Amyloid Beta 1-42 Pre-formed Fibrils-其他肽-ELISA_抗体_蛋白_核苷酸

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Amyloid Beta 1-42 Pre-formed Fibrils

品牌：Stressmarq

官网链接

说明书

折扣/货期

货号：SPR-487C

规格：100 µg x2

目录价：￥7698.6

产品详情

产品名称:

Amyloid Beta 1-42 Pre-formed Fibrils

别名:

Abeta Protein, Abeta peptide, Amyloid beta peptide, Beta amyloid peptide, amyloid beta precursor protein peptide, APP

产品描述:

Human Synthetic Amyloid Beta 1-42 Pre-formed Fibrils

反应种属:

Human

实验应用:

WB | In vivo Assay | In vitro Assay

纯化方式:

N/A

偶联:

No Tag

产品浓度:

1 mg/ml

表达系统:

N/A

保存温度:

-80ºC

运输温度:

Dry Ice. Shipping note: Product will be shipped separately from other products purchased in the same order.

预期分子量:

4.5 kDa

存储溶液:

10 mM HCl + 2% DMSO

产地:

加拿大

功能与背景:

Our Amyloid Beta 1-42 (Aβ42) Pre-formed Fibrils are generated from Amyloid Beta Peptide 1-42 pre-treated with 1,1,1,3,3,3-Hexafluoro-2-propanol (HFIP) using a previously published method (1,2). Our Aβ42 fibrils present as long strands when observed under TEM and AFM, and have a unique high molecular weight signal on a Western Blot with an anti-amyloid beta antibody. Our Aβ42 fibrils were also demonstrated to be toxic to primary rat cortical neurons in a dose-dependent manner after an initial sonication step. In the brain, amyloid beta peptide (Aβ) is generated by protease cleavage of amyloid precursor protein (APP), which aggregates into oligomers, protofibrils, fibrils and ultimately plaques in neurodegenerative diseases. The accumulation of Aβ plaques in the brain is considered a hallmark of Alzheimer’s disease (AD), and most of the drugs tested for AD in the past 20 years have targeted amyloid beta accumulation (3). Soluble Aβ oligomers isolated from the brains of AD patients or those generated in vitro potently impaired synapse structure and function (4). Aβ oligomers generated in vitro were toxic to PC12 cells (2) and SH-SY5Y cells (5). Aβ was demonstrated to interact with tauopathies to affect neurodegeneration in AD patients (6) and accumulations of Aβ were shown to be associated with lower survival rates in Parkinson’s disease patients with dementia (7).

纯度:

>95%

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