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折扣/货期| 货号：AG-40B-0145-3010 | 规格：3 x 10 ug | 目录价：￥3840 |
| 货号：AG-40B-0145-C010 | 规格：10 ug | 目录价：￥1920 |
产品详情
产品名称:
ANGPTL8 [Betatrophin] (human):Fc (human) (rec.) MultiPack
别名:
Angiopoietin-like Protein 8; ANGPTL8; Lipasin; Refeeding-induced Fat and Liver Protein; RIFL; Betatrophin
产品描述:
ANGPTL8 (Angiopoietin-like protein 8; RIFL; Lipasin; Betatrophin) is a newly discovered secreted protein of 198 aa that was proposed to promote beta cell proliferation and improve glucose tolerance in mice. ANGPTL8 may also function in inhibition of lipase activity and on serum triglyceride regulation. ANGPTL8 is expressed in the liver and in white and brown adipose tissue of mice. In humans, ANGPTL8 is found to be predominantly expressed in the liver. ANGPTL8 levels are reduced by fasting and are elevated upon insulin resistance and during pregnancy. ANGPTL8, according to preliminary data could bind to the macrophage receptor Marco and also to RTN4R, a neuronal receptor. Recently, a study using ANGPTL8 KO mice showed that ANGPTL8 does not play a role in beta cell proliferation nor in glycemic control as previously thought, but regulates plasma triglyceride levels.
宿主来源:
HEK 293 cells
产品浓度:
0.1mg/ml after reconstitution
保存温度:
-20°C
运输温度:
BLUE ICE
预期分子量:
~50kDa
产品形式:
solid
存储溶液:
Lyophilized. Contains PBS + 0.02% CHAPS.
有效期:
Stable for at least 6 months after receipt when stored at -20°C. Working aliquots are stable for up to 3 months when stored at -20°C.
产地:
瑞士
纯度:
>90% (SDS-PAGE)
生物活性:
Betatrophin (human):Fc (human) (rec.) binds to human Angiopoietin-3 in a ELISA binding assay with an EC50 of ~250-300 ng/ml.
内毒素水平:
<0.01EU/µg purified protein (LAL test).
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