CD279 [PD-1] (mouse):Fc (human) (rec.)-Fc融合蛋白-ELISA_抗体_蛋白_核苷酸

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CD279 [PD-1] (mouse):Fc (human) (rec.)

品牌：Adipogen

官网链接

说明书

折扣/货期

货号：CHI-MF-111PD1-C100

规格：100 ug

目录价：￥5040

产品详情

产品名称:

CD279 [PD-1] (mouse):Fc (human) (rec.)

别名:

PD-1; Programmed Cell Death Protein 1; SLEB2

产品描述:

CD279 (Programmed Cell Death Protein 1; PD-1) is a type I transmembrane protein belonging to the CD28/CTLA-4 family of immunoreceptors that mediate signals for regulating immune responses. Members of the CD28/CTLA-4 family have been shown to either promote T cell activation (CD28 and ICOS) or downregulate T cell activation (CTLA-4 and PD-1). CD279 is expressed on activated T cells, B cells, myeloid cells and on a subset of thymocytes. In vitro, ligation of CD279 inhibits TCR-mediated T cell proliferation and production of IL-1, IL-4, IL-10 and IFN-gamma. In addition, CD279 ligation also inhibits BCR mediated signaling. CD279 deficient mice have a defect in peripheral tolerance and spontaneously develop autoimmune diseases.

宿主来源:

HEK 293 cells

保存温度:

-20°C

运输温度:

BLUE ICE

预期分子量:

~42kDa (SDS-PAGE)

产品形式:

solid

存储溶液:

Lyophilized from 0.2µm-filtered solution in PBS.