CD152 [CTLA-4] (mouse):Fc (mouse) (rec.) (non-lytic)-Fc融合蛋白-ELISA_抗体_蛋白_核苷酸

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CD152 [CTLA-4] (mouse):Fc (mouse) (rec.) (non-lytic)

品牌：Adipogen

官网链接

说明书

折扣/货期

货号：CHI-MF-120A4-C100	规格：100 ug	目录价：￥1540
货号：CHI-MF-120A4-C500	规格：500 ug	目录价：￥4340

产品详情

产品名称:

CD152 [CTLA-4] (mouse):Fc (mouse) (rec.) (non-lytic)

别名:

CTLA-4

产品描述:

CD152 [CTLA-4] and CD28, together with their ligands B7-1 and B7-2, constitute one of the dominant costimulatory pathways that regulate T and B cell responses. CD152 and CD28 are structurally homologous molecules that are members of the immunoglobulin (Ig) gene superfamily. Both CD152 and CD28 are composed of a single Ig V-like extracellular domain, a transmembrane domain and an intracellular domain. CD152 and CD28 are both expressed on the cell surface as disulfide-linked homodimers or as monomers. CD152 was originally identified as a gene that was specifically expressed by cytotoxic T lymphocytes. However, CD152 transcripts have since been found in both Th1 and Th2, and CD4+ and CD8+ T cell clones. Whereas, CD28 expression is constitutive on the surfaces of 95% of CD4+ T cells and 50% of CD8+ T cells and is down regulated upon T cell activation, CD152 expression is upregulated rapidly following T cell activation and peaks approximately 24 hours following activation. Although both CD152 and CD28 can bind to the same ligands, CD152 binds to B71 and B72 with 20-100-fold higher affinity than CD28.

宿主来源:

NS1 cells

保存温度:

-20°C

运输温度:

BLUE ICE

产品形式:

solid

存储溶液:

Lyophilized from 0.2µm-filtered solution in PBS.

有效期:

Stable for at least 1 year after receipt when stored at -20°C. Working aliquots are stable for up to 3 months when stored at -20°C.

产地:

瑞士

纯度:

>98% (SDS-PAGE)

生物活性:

Blocks the binding of mouse CD80 (B7-1) and CD86 (B7-2) to their receptors (by binding CD80 and CD86 with high affinity) and thereby prevents their T cell regulatory actions by inhibiting the CD28 signaling competitively. Shows the biological functions of the CD152 moiety and exerts a prolonged circulating half-life caused by the modified Fc domain. Useful for investigating the T cell co-stimulation.

内毒素水平:

<1EU/mg protein (LAL test; Lonza).

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