B7-H4 (human):Fc (human) (rec.)-Fc融合蛋白-ELISA_抗体_蛋白_核苷酸

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B7-H4 (human):Fc (human) (rec.)

品牌：Adipogen

官网链接

说明书

折扣/货期

货号：CHI-HF-210B7H4-C100

规格：100 ug

目录价：￥5390

产品详情

产品名称:

B7-H4 (human):Fc (human) (rec.)

别名:

V-set Domain-containing T Cell Activation Inhibitor 1; VTCN1; B7h.5; Immune Costimulatory Protein B7-H4; T Cell Costimulatory Molecule B7x; Protein B7S1

产品描述:

B7-H4 is a B7 family member that negatively regulates T cell immunity by inhibiting of T cell proliferation, cytokine production, and cell cycle progression. In vitro, B7-H4 inhibits CD4+ and CD8+ T cell proliferation, cytokine production, and generation of alloreactive cytotoxic T-cells (CTLs). In vivo, blockade of endogenous B7-H4 by specific monoclonal antibody promotes T cell responses. B7-H4 ia an important negative regulator of innate immunity through growth inhibition of neutrophils. B7-H4 is expressed on some tumor cancer cells. The role of B7-H4 in tumor progression may be to transform precancerous cells and then protect them from immunosurveillance.

宿主来源:

CHO cells

保存温度:

-20°C

运输温度:

BLUE ICE

产品形式:

solid

存储溶液:

Lyophilized from 0.2µm-filtered solution in PBS.

有效期:

Stable for at least 1 year after receipt when stored at -20°C. Working aliquots are stable for up to 3 months when stored at -20°C.

产地:

瑞士

纯度:

>98% (SDS-PAGE)

生物活性:

Measured by the ablility to inhibit anti-CD3-induced proliferation of stimulated human T cells. Human T lymphocytes cultured for 72 hours with PHA were incubated for an additional 3 days in 96 well place coated with 500ng/ml anti-CD3 and 10µg/ml human B7H4/Fc. The presence of human B7H4/Fc at 10µg/ml inhibited anti CD3 response by 30-50%. Optimal dilutions should be determined by each laboratory for each application.

内毒素水平:

<0.06EU/µg protein (LAL test; Lonza).

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