货号:CHI-HF-210A4-C100 | 规格:100 ug | 目录价:¥1400 |
货号:CHI-HF-210A4-C500 | 规格:500 ug | 目录价:¥3780 |
产品详情
产品名称:
CD152 [CTLA-4] (human):Fc (human) (rec.)
别名:
CTLA-4
产品描述:
CD152 [CTLA-4] and CD28, together with their ligands B7-1 and B7-2, constitute one of the dominant costimulatory pathways that regulate T and B cell responses. CD152 and CD28 are structurally homologous molecules that are members of the immunoglobulin (Ig) gene superfamily. Both CD152 and CD28 are composed of a single Ig V-like extracellular domain, a transmembrane domain and an intracellular domain. CD152 and CD28 are both expressed on the cell surface as disulfide-linked homodimers or as monomers. CD152 was originally identified as a gene that was specifically expressed by cytotoxic T lymphocytes. However, CD152 transcripts have since been found in both Th1 and Th2, and CD4+ and CD8+ T cell clones. Whereas, CD28 expression is constitutive on the surfaces of 95% of CD4+ T cells and 50% of CD8+ T cells and is down regulated upon T cell activation, CD152 expression is upregulated rapidly following T cell activation and peaks approximately 24 hours following activation. Although both CD152 and CD28 can bind to the same ligands, CD152 binds to B71 and B72 with 20-100-fold higher affinity than CD28.
宿主来源:
CHO cells
保存温度:
-20°C
运输温度:
BLUE ICE
产品形式:
solid
存储溶液:
Lyophilized from 0.2µm-filtered solution in PBS.
有效期:
Stable for at least 1 year after receipt when stored at -20°C. Working aliquots are stable for up to 3 months when stored at -20°C.
产地:
瑞士
纯度:
>98% (SDS-PAGE)
生物活性:
Binds both CD80 (B7-1) and CD86 (B7-2) with high affinity and inhibits CD28 signaling competitively. Kills the target cell completely.
内毒素水平:
<0.06EU/µg protein (LAL test; Lonza).
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