官网链接
折扣/货期| 货号：AG-40B-0119-3010 | 规格：3 x 10 ug | 目录价：￥4800 |
| 货号：AG-40B-0119-C010 | 规格：10 ug | 目录价：￥2400 |
| 货号：AG-40B-0119-C100 | 规格：100 ug | 目录价：￥9600 |
产品详情
产品名称:
Fc (human):FLT3 Ligand (human) (rec.) MultiPack
别名:
FMS-like Tyrosine Kinase 3 Ligand
产品描述:
FMS-like tyrosine kinase 3 ligand (FLT3L) acts as a growth factor that increases the number of immune cells (lymphocytes (B cells and T cells)) by activating the hematopoietic progenitors. It binds to FLT3 (CD135) which is found on multipotent progenitor (MPP) and common lymphoid progenitor (CLP) cells in mice. FLT3L induces the mobilization of the hematopoietic progenitors and stem cells in vivo which may help the system to kill cancer cells. FLT3L is crucial for steady-state pDC (plasmacytoid dendritic cells) and cDC (classical dendritic cells) development. Deficiency of FLT3L causes a dramatic decrease in DC numbers, whereas increasing its availability increase in DC numbers.
宿主来源:
CHO cells
靶标/特异性:
Binds to human and mouse FLT3 receptor.
产品浓度:
1mg/ml
保存温度:
-20°C
运输温度:
BLUE ICE
产品形式:
liquid
存储溶液:
Liquid. In PBS (sterile).
有效期:
Stable for at least 6 months after receipt when stored at -20°C. Working aliquots are stable for up to 3 months when stored at -20°C.
产地:
瑞士
纯度:
>95% (SDS-PAGE)
生物活性:
In vitro and in vivo generation of conventional and plasmacytoid dendritic cells (DC). FLT3L increases in vivo both NK and DC cells numbers in the spleen when mice are injected intraperitoneally with 2 or 10 µg, daily for 10 days (slightly higher effect at 10 µg).
内毒素水平:
<0.1EU/µg purified protein (LAL test; Lonza).
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