Histone H3 (Citrullinated R2 + R8 + R17) Monoclonal Antibody (Clone 11D3)-单抗-ELISA_抗体_蛋白_核苷酸

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Histone H3 (Citrullinated R2 + R8 + R17) Monoclonal Antibody (Clone 11D3)

品牌：Cayman

官网链接

说明书

折扣/货期

货号：17939

规格：100 µg

目录价：￥5600

产品详情

产品名称:

Histone H3 (Citrullinated R2 + R8 + R17) Monoclonal Antibody (Clone 11D3)

产品描述:

Histone H3 is a nuclear protein and a component of the nucleosome core that is essential for organizing genomic DNA in eukaryotic nuclei.{56209} It is a globular protein that contains an unstructured N-terminal tail that extends outside of the nucleosome core and is subject to various post-translational modifications, including citrullination. Histone H3 is subject to citrullination of arginine residues by peptidyl arginine deiminase 4 (PAD4) at positions 2, 8, 17 and 26, and this citrullination blocks methylation of these residues by protein-arginine methyltransferase 4 (PRMT4) and induces transcriptional repression of target genes. Citrullinated histone H3 is a component of neutrophil extracellular traps (NETs) that acts as an autoantigen to induce production of anti-citrullinated protein antibodies associated with various diseases such as sepsis, multiple sclerosis, rheumatoid arthritis, and multiple myeloma.{56209,30129,35770,46253} Cayman’s Histone H3 (Citrullinated R2 + R8 + R17) Monoclonal Antibody can be used for ELISA and Western blot applications. The antibody recognizes citrullinated histone H3 at approximately 16 kDa from human samples.

宿主来源:

Mouse

实验应用:

ELISA and WB

同种型:

IgG1K

免疫原:

Histone H3 peptide with citrulline at R2, R8, and R17

克隆号:

11D3

保存温度:

-20