STING Monoclonal Antibody (Clone 2C8)-单抗-ELISA_抗体_蛋白_核苷酸_试剂盒-深圳欣博盛生物科技有限公司

首页产品中心单抗

STING Monoclonal Antibody (Clone 2C8)

品牌：Cayman

官网链接

说明书

折扣/货期

货号：17856

规格：100 µg

目录价：￥5096

产品详情

产品名称:

STING Monoclonal Antibody (Clone 2C8)

别名:

产品描述:

Stimulator of Interferon Genes (STING) is a component of the innate immune response. STING binds to cyclic dinucleotides, which are bacterial second messengers.{24607} Recognition of cyclic-di-GMP (c-di-GMP), c-di-AMP, or c-GMP-AMP leads to activation of NF-κB and transcription of immunomodulatory genes, including type I interferon (IFN).{22400,22401,24611} Loss of STING regulation contributes to autoimmune disorders through increased IFN activity.{24608} The gene for STING is mutated in the mouse strain Goldenticket, which consequently lacks a type I IFN response to Listeria infection.{24612} Activation of STING by the flavonoid 5,6-dimethylxanthenone-4-acetic acid (DMXAA; Item No. 14617) has been shown to kill solid tumors in mice, but the binding site of DMXAA is not conserved in human STING.{24610,24609} Cayman’s STING Monoclonal Antibody (Clone 2C8) can be used for ELISA, immunohistochemistry, and Western blot applications. The antibody recognizes STING at 42 kDa from human samples.

宿主来源:

Mouse

实验应用:

ELISA, IHC, and WB

同种型:

IgG1

免疫原:

Human recombinant STING protein AA 139-379

克隆号:

2C8

保存温度:

-20