货号:17856 | 规格:100 µg | 目录价:¥5096 |
产品详情
产品名称:
STING Monoclonal Antibody (Clone 2C8)
别名:
Endoplasmic Reticulum Interferon Stimulator|ERIS|Mediator of IRF3 Activation|MITA|MPYS|Stimulator of Interferon Genes|TMEM173|Transmembrane Protein 173
产品描述:
Stimulator of Interferon Genes (STING) is a component of the innate immune response. STING binds to cyclic dinucleotides, which are bacterial second messengers.{24607} Recognition of cyclic-di-GMP (c-di-GMP), c-di-AMP, or c-GMP-AMP leads to activation of NF-κB and transcription of immunomodulatory genes, including type I interferon (IFN).{22400,22401,24611} Loss of STING regulation contributes to autoimmune disorders through increased IFN activity.{24608} The gene for STING is mutated in the mouse strain Goldenticket, which consequently lacks a type I IFN response to Listeria infection.{24612} Activation of STING by the flavonoid 5,6-dimethylxanthenone-4-acetic acid (DMXAA; Item No. 14617) has been shown to kill solid tumors in mice, but the binding site of DMXAA is not conserved in human STING.{24610,24609} Cayman’s STING Monoclonal Antibody (Clone 2C8) can be used for ELISA, immunohistochemistry, and Western blot applications. The antibody recognizes STING at 42 kDa from human samples.
宿主来源:
Mouse
实验应用:
ELISA, IHC, and WB
同种型:
IgG1
免疫原:
Human recombinant STING protein AA 139-379
克隆号:
2C8
保存温度:
-20
运输温度:
-20
产品形式:
100 µg of protein G-purified monoclonal antibody
有效期:
1095
上一个:Renin Monoclonal Antibody (Clone 3G10)
下一个:Histone H3 (Citrullinated R2 + R8 + R17) Monoclonal Antibody (Clone 11D3)
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