Histone H3S10Ph Monoclonal Antibody (Clone RM163)-单抗-ELISA_抗体_蛋白_核苷酸

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Histone H3S10Ph Monoclonal Antibody (Clone RM163)

品牌：Cayman

官网链接

说明书

折扣/货期

货号：20720

规格：100 µg

目录价：￥7408

产品详情

产品名称:

Histone H3S10Ph Monoclonal Antibody (Clone RM163)

别名:

H3pS10|H3pSer10|Histone H3 (Phospho-Ser10)|Phospho-Histone H3 Serine 10|Phosphorylated Histone H3 Serine 10

产品描述:

Histone H3 is a nuclear protein and a component of the nucleosome core, a basic unit of chromatin, that is essential for organizing genomic DNA in eukaryotic nuclei.{57056} It is a globular protein that contains an unstructured N-terminal tail that extends outside of the nucleosome core and is subject to various post-translational modifications (PTMs), including methylation, phosphorylation, acetylation, and citrullination.{57056,53978} Phosphorylation of histone H3 at serine 10 (H3S10Ph) is correlated with chromatin condensation during mitosis and with transcriptional activation of genes during interphase.{47274,32235} H3S10Ph does not inhibit binding of the ADD domain of the chromatin-remodeling protein ATRX to histone H3 N-terminal peptides due to its positioning away from the core peptide binding sequence but does decrease binding of the HP1α chromodomain (CD) when the histone H3 peptide is also trimethylated at lysine 9.{47275} Low median levels of H3S10Ph in tumor tissue isolated from patients with oral squamous cell carcinoma (OSCC) are associated with cervical lymph node metastasis.{54491} Cayman's Histone H3S10Ph Monoclonal Antibody (Clone RM163) can be used for ELISA, immunocytochemistry (ICC), multiplex-based assay, and Western blot (WB) applications.

宿主来源:

Rabbit

实验应用:

ELISA, ICC, multiplex-based assay, WB

同种型:

IgG

免疫原:

Peptide corresponding to H3S10Ph

克隆号:

RM163

保存温度:

-20